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AJNR - American Journal of Neuroradiology

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Dedifferentiated Chondrosarcoma of the Larynx

Osamu Sakai ^a, Hugh D. Curtin ^,a, William C. Faquin ^a and Richard L. Fabian ^a

^a From the Departments of Radiology (O.S., H.D.C.), Pathology (W.C.F.), and Head and Neck Surgery (R.L.F.), Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA.

View larger version (60K): [in a new window]   FIG 1. A, Soft-tissue window axial contrast-enhanced CT through thyroid cartilage shows expansile lesion from left alar of thyroid cartilage. Multiple rings, calcification arcs, and relatively intact cortex suggest chondroid lesion. False cord is significantly displaced. Note large soft-tissue component extending anterolaterally into strap muscles and incomplete cortex at point (arrows). B, Bone window of expansile lesion shown in panel A. C, Bone window axial CT scan obtained through vocal cord level shows mass representing typical chondroid lesion with multiple rings and calcification arcs (arrow) and well-preserved cortex at this level. D, Histologic section from laryngectomy specimen shows features of dedifferentiated chondrosarcoma. Area of low-grade chondrosarcoma is on left, juxtaposed to malignant fibrous histiocytoma-like area of high-grade sarcoma on right (H&E, original magnification x125).