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AJNR - American Journal of Neuroradiology

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Subcortical Ischemic Vascular Dementia: Assessment with Quantitative MR Imaging and ¹H MR Spectroscopy

Aristides A. Capizzano^a, Norbert Schuff^a, Diane L. Amend^a, Jody L. Tanabe^a, David Norman^a, Andrew A. Maudsley^a, William Jagust^a, Helena C. Chui^a, George Fein^a, Mark R. Segal^a and Michael W. Weiner^,a

^a From the Department of Veterans Affairs Medical Center (A.A.C., N.S., D.L.A., J.L.T., A.A.M., M.W.W.), Magnetic Resonance Spectroscopy Unit, San Francisco, CA; the Departments of Radiology (A.A.C., N.S., D.L.A., J.L.T., D.N., M.W.W.), Medicine (M.W.W.), Psychiatry (G.F., M.W.W.), and Neurology (M.W.W.) and the Division of Biostatistics (M.R.S.), University of California, San Francisco, San Francisco, CA; The Center for Functional Imaging (W.J.), Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA; and the Department of Neurology (H.C.C.), University of Southern California, Rancho Los Amigos Medical Center, Downey, CA.

View larger version (147K): [in a new window]   FIG 1. Various MR images are shown for comparison. A, Sagittal MR image shows outlines of multisection (two upper boxes) and PRESS (lower box) volumes of interest. B, Axial T1-weighted MR image shows defined PRESS volume (inner box), field of view (outer box), and positions of the individual voxels extracted for data analysis (circles). C, Ventricular proton density–weighted axial MR image displaying positions of selected voxels for multisection data analysis (circles). D, Supraventricular proton density–weighted axial MR images displaying positions of selected voxels for multisection data analysis (circles).

View larger version (7K): [in a new window]   FIG 2. Spectrum selected in normal-appearing white matter (left) and spectrum from a white matter signal hyperintensity (right) show evident reduction in the NAA peak amplitude at 2.02 ppm in the latter

View larger version (24K): [in a new window]   FIG 3. Scatter plot displays the correlation between white matter signal hyperintensity and ventricular volumes for patients with lacunes. FIG 4. Scatter plot displays the correlation between cortical and ventricular volumes for patients with lacunes. FIG 5. Scatter plot displays the correlation between frontal cortical NAA and supratentorial lacune count for all patients with lacunes