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Proton MR Spectroscopy in Children with Bipolar Affective Disorder: Preliminary Observations

Mauricio CastilloGo,a, Lester Kwocka, Helen Courvoisiea and Stephen R. Hoopera

a From the Departments of Radiology (M.C., L.K.) and Psychiatry (H.C., S.R.H.), University of North Carolina School of Medicine, Chapel Hill.



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  		FIG 1. A and B, Axial T1-weighted images show placement of voxel in the left frontal lobe (A) and in the left temporal lobe (B)



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  		FIG 2. MR spectra from the frontal lobes.

A, Proton spectra from the left frontal lobe in a control subject show normal metabolites. C, choline; Cr, creatine; N, NAA.

B, Proton spectra from the left frontal lobe in a patient with BPAD show prominent resonances between 2.1 and 2.5 ppm, corresponding to Glu/Gln (G). The resonances between 0.8 and 1.8 ppm correspond to lipids (L). C, choline; Cr, creatine; N, NAA.



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  		FIG 3. MR spectra from the temporal lobes.

A, Proton spectra from the left temporal lobe in a control subject show normal metabolites.

B, Proton spectra from the left temporal lobe in a patient with BPAD show prominent Glu/Gln (G) but no lipids. C, choline; Cr, creatine; N, NAA.



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  		FIG 4. MR spectra from the frontal lobes in a patient with BPAD obtained with smaller voxels.

A, Axial T1-weighted localizer image with grid shows dense. White square outlines the area of analysis. Study was obtained with 2D PRESS technique (TE = 135). Note location of individual voxel (arrow), corresponding to spectra in B.

B, Proton spectra from voxel (arrow, A; 1 x 1 x 1.5 cm) show marked elevation of lipids (L). Note that voxel is far away from any fat-containing structure, precluding extraneous contamination. C, choline; Cr, creatine; N, NAA.

C, Proton spectra of individual voxel placed contralateral and in nearly a mirror position to B still show marked elevation of lipids (L). Again, voxel is placed away from fat-containing structures that could conceivably contaminate it. C, choline; Cr, creatine; N, NAA.





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X