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AJNR - American Journal of Neuroradiology

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Demyelinating Plaques in Relapsing-remitting and Secondary-progressive Multiple Sclerosis: Assessment with Diffusion MR Imaging

Alessandro Castriota Scanderbeg^a, Francesco Tomaiuolo^a, Umberto Sabatini^a, Ugo Nocentini^a, Maria G. Grasso^a and Carlo Caltagirone^a

^a From the Departments of Radiology (A.C-S., F.T., U.S.) and Neurology (M.G.G.), I.R.C.C.S., S. Lucia, Rome, Italy; and from the Department of Neurology (U.N., C.C.), University Tor Vergata, Rome, Italy.

View larger version (140K): [in a new window]   FIG 1. A–D, Axial SE T1-weighted (A), fast SE T2-weighted (B), and echo-planar T2-weighted (C) MR images, and the orientationally averaged ADC map (D), show the presence of multiple periventricular demyelinating lesions in a patient with secondary-progressive MS. Circle indicates the ROI

View larger version (11K): [in a new window]   FIG 2. Scatter plot of the coefficient <D> data points for the relapsing-remitting (RR, 10 points), secondary-progressive (SP, 10 points), and control group (NWM, normal white matter, 11 points). Each point corresponds to one subject and represents the mean value of <D> as obtained in each subject from all the ROIs that were drawn on the T2-weighted (b = 0) images. Graph shows there is no overlap between the relapsing-remitting and secondary-progressive groups

View larger version (14K): [in a new window]   FIG 3. Scatter plot of the coefficient <D> vs. EDSS score shows a significant correlation. Each point corresponds to one patient and represents the mean value of <D> as obtained from all the ROIs that were drawn on the T2-weighted (b = 0) images. Closed circles represent the subjects with relapsing-remitting MS; open circles, the subjects with secondary-progressive MS

View larger version (16K): [in a new window]   FIG 4. Scatter plot of coefficient <D> vs. disease duration shows a significant correlation. Each point corresponds to one patient and represents the mean value of <D> as obtained from all the ROIs that were drawn on the T2-weighted (b = 0) images. Closed circles represent the patients with relapsing-remitting MS; open circles, the patients with secondary-progressive MS

View larger version (9K): [in a new window]   FIG 5. Scatter plot of coefficient <D> vs. SIlesion/SICSF ratio on SE T1-weighted images for the 41 T1 hypointense lesions studied. There is a significant inverse correlation between <D> and SIlesion/SICSF ratio. Each point corresponds to one lesion. Closed circles represent lesions from the relapsing-remitting group (11 lesions); open circles, lesions from the secondary-progressive group (30 lesions)