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The Utility of the Microcrystalline Cellulose Sphere as a Particulate Embolic Agent:An Experimental Study

Yutaka KaiGo,a, Jun-ichiro Hamadaa, Motohiro Moriokaa, Tatemi Todakaa, Shu Hasegawaa and Yukitaka Ushioa

a From the Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan.



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  		FIG 1. Scanning electron micrograph of 200-µm -diameter CELPHERE beads. They are spherical and of accurately calibrated size. The bar represents 500 µm



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  		FIG 2. A, Preembolization angiogram shows the typical canine renal arterial system.

B, Angiogram obtained 1 hour after embolization shows complete occlusion of the main renal artery and the radiodensity of the CELPHERE cast.

C, Angiogram obtained 12 weeks after embolization shows no evidence of recanalization of the embolized main renal artery.



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  		FIG 3. Section obtained 12 weeks after embolization. Large vessels were packed with aggregated CELPHERE beads. The beads traveled to vessels approximately 200 µm in diameter without stretching the vessel wall or rupturing the internal elastic lamina. There is no evidence of perivascular hemorrhage or inflammatory change in the peripheral area. (Hematoxylin & eosin stain: A, original magnification x40; B, original magnification x100)





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X