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AJNR - American Journal of Neuroradiology

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Functional MR Imaging Activation after Finger Tapping Has a Shorter Duration in the Basal Ganglia Than in the Sensorimotor Cortex

Chad H. Moritz^,a, M. Elizabeth Meyerand^a, Dietmar Cordes^a and Victor M. Haughton^a

^a From the Departments of Radiology (C.H.M., V.M.H.) and Medical Physics (M.E.M., D.C.), University of Wisconsin, Madison.

View larger version (11K): [in a new window]   FIG 1. Reference functions and task timing

View larger version (163K): [in a new window]   FIG 2. A–F, Functional MR images comparing activation detected by reference function 1 (right-handed task) (A–C) and reference function 2 (left-handed task) (D–F). Activation is detected in the SMC, thalamus, putamen, and cerebellum; activation is contralateral to the fingers that were active in the SMC and the thalamus, bilateral in the putamen, and ipsilateral in the cerebellum. (Note that all images are conventional radiologic display format, with the subject's right side appearing on the viewer's left.)

View larger version (98K): [in a new window]   FIG 3. A and B, Functional MR images showing subcortical activation for the same subject as in figure 2 detected by reference function 3 (right-handed initiation) (A) and reference function 4 (left-handed initiation) (B). Activation is detected in the putamen, thalamus, and transverse temporal gyrus. As compared with reference functions 1 and 2 (see fig 2B and E), more activation is detected in the putamen

View larger version (93K): [in a new window]   FIG 4. Functional MR images showing activation detected by reference function 5. Activation is detected in the SMC, SMA, thalamus, and cerebellum. As compared with the other reference functions (figs 2 and 3), activation is detected bilaterally in the SMC, thalamus, and cerebellum, but with decreased specificity for the SMC

View larger version (34K): [in a new window]   FIG 5. Representative time courses from selected ROIs. A, Right and left primary motor cortex. B, Right and left superior cerebellum. C, Right and left inferior cerebellum. D, Right and left thalamus. E, Right and left SMA. F, Right and left putamen.

View larger version (6K): [in a new window]   FIG 6. A and B, Time courses are averaged across the four epochs from representative pixels in the right and left putamen (A) and left and right primary motor cortex (B). Vertical gray lines indicate timing intervals for the initiation of each 20-second cycle of right- and left-handed activation and rest