Magnetization Transfer Measurements of the Hippocampus in Patients with Alzheimer's Disease, Vascular Dementia, and Other Types of Dementia
Haruo Hanyu
,a,
Tetsuichi Asanoa,
Toshihiko Iwamotoa,
Masaru Takasakia,
Hiroaki Shindoa and
Kimihiko Abea
a From the Departments of Geriatric Medicine (H.H., T.A., T.I., M.T.) and Radiology (H.S., K.A.), Tokyo Medical University, Tokyo, Japan.
View larger version (131K):
[in a new window]
|
FIG 1. Sample images and the subjective rating scale of medial temporal lobe atrophy: 0 = absent, 1 = minimal, 2 = mild, 3 = moderate, 4 = severe
| |
View larger version (26K):
[in a new window]
|
FIG 2. Mean scores of medial temporal lobe atrophy in patients with AD, vascular dementia (VaD), other dementias, and control subjects. Post hoc Mann-Whitney U test showed significant differences between all dementia groups and control subjects
| |
View larger version (33K):
[in a new window]
|
FIG 3. Mean MT ratios in patients with AD, vascular dementia, other dementias, and in control subjects. Post hoc Scheffé test showed significant differences between AD and vascular dementia (VaD) (P < .01), between AD and other dementias (P < .0001), and between AD and control subjects (P < .0001)
| |
View larger version (66K):
[in a new window]
|
FIG 4. 76-year-old woman with AD.
A, Gradient-echo Mo image (390/12/2), acquired without a radio frequency saturation pulse, shows moderate atrophy of the medial temporal lobe, graded as 3 using the visual rating scale.
B, Ms image, acquired with a radio frequency saturation pulse, shows slightly high signal intensity in areas of hippocampal formation (arrowheads).
C, Calculated MT ratio image shows slightly low signal intensity in areas of the hippocampus (arrowheads) (MT ratio = 34.2%).
| |
View larger version (9K):
[in a new window]
|
FIG 5. Correlations between MMSE scores and MT ratios in AD and non-AD dementia (Pearson's correlation coefficients). The MT ratio significantly correlated with the MMSE score in patients with AD but not in patients with non-AD dementia. Non-AD dementia includes vascular dementia and other dementias (NS indicates not significant)
| |
View larger version (9K):
[in a new window]
|
FIG 6. Correlations between MT ratios and scores of medial temporal lobe atrophy in AD and non-AD dementia (Spearman's rank correlation coefficients). The MT ratio significantly correlated with the score of medial temporal lobe atrophy in patients with AD but not in patients with non-AD dementia. Non-AD dementia includes vascular dementia and other dementias (NS indicates not significant)
| |
