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AJNR - American Journal of Neuroradiology

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Functional MR Imaging Analysis of Pain-related Brain Activation after Acute Mechanical Stimulation

Christelle Créac'h^a, Patrick Henry^a, Jean Marie Caillé^a and Michéle Allard^,a

^a From INSERM U.378 (M.A.) and Service de Neuroradiologie/Neurologie CHU de Bordeaux (C.C., P.H., J.M.C.).

View larger version (12K): [in a new window]   FIG 1. Time course of region of interest intensity in the secondary somesthesic cortex. The + sign represents each dynamic scan. Activation periods are represented on the abscissa (images 15–25 and 35–45). The five first images acquired were discarded from postprocessing analysis. Imaging parameters included 3000/60 (TR/TE) and a 5-mm section thickness in a 7-minute 30-second sequence with 2 x 90 seconds of painful stimulation interleaved with 3 x 90 seconds of innocuous stimulation. Functional images were processed using dedicated IDL software

View larger version (191K): [in a new window]   FIG 2. Cortical activation during noxious mechanical stimulation of the left hand in one subject. Imaging parameters included 3000/60 (TR/TE) and a 5-mm section thickness in a 7-minute30-second sequence with 2 x 90 seconds of painful stimulation interleaved with 3 x 90 seconds of innocuous stimulation. Functional images were processed using dedicated IDL software. Activation maps are shown on six representative slices. R: right side; L: left side. Contralateral primary somatosensory (*), bilateral superior parietal (+) and insular (open square) cortices. Colored scale represents the correlation coefficient between time-series data and the box-car reference waveform that corresponded to the task sequence threshold