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AJNR - American Journal of Neuroradiology

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Mapping Functionally Related Regions of Brain with Functional Connectivity MR Imaging

Dietmar Cordes^a, Victor M. Haughton^,a, Konstantinos Arfanakis^a, Gary J. Wendt^a, Patrick A. Turski^a, Chad H. Moritz^a, Michelle A. Quigley^a and M. Elizabeth Meyerand^a

^a From the Departments of Radiology (V.M.H., G.J.W., P.A.T., C.H.M.) and Medical Physics (D.C., K.A., M.A.Q., M.E.M.), University of Wisconsin, Madison.

View larger version (39K): [in a new window]   FIG 1. A and B, Selected coronal and axial fMRI maps of voxels activated by the bilateral finger-tapping task (A) and of the voxels functionally connected to a seed voxel (crosshairs) in the sensorimotor cortex in a resting acquisition (B). The sensorimotor cortex is identified on both the fMRI and the fcMRI maps. Voxels within the dentate nucleus of the cerebellum were identified with fMRI but not with the functional connectivity study

View larger version (30K): [in a new window]   FIG 2. A and B, Consecutive coronal fMRI maps of voxels activated by a text-listening task (A) and of the voxels functionally connected with a 2 x 2 seed voxel ROI (crosshairs) within the auditory cortex (B). Task activation was evident in the region of the primary and association auditory cortices in the superior temporal lobe. Many of the voxels functionally connected with the seed voxel in the left auditory cortex (crosshairs) have a similar distribution. A few other voxels with lower correlation coefficients (red) were identified outside the auditory cortices. For the connectivity study, data were collected without the patient performing a specific cognitive task

View larger version (34K): [in a new window]   fig 3. A and B, A coronal image showing task activation for the text-listening task (A) and connectivity for a seed voxel (crosshairs) in the left frontal lobe in a resting data set (B). The task produces activation in the superior temporal gyral regions bilaterally and in the left frontal lobe in or near Broca's region. Activation is also identified in the right frontal lobe. The voxels with connectivity to the seed voxel (crosshairs) appear to lie in similar locations. fig 4. A and B, Coronal images showing task activation for the word-generation task (A) and connectivity for the left frontal cortex in the region that showed task activation (B). The task produced activation in the left frontal lobe in or near Broca's area and in the superior temporal lobes bilaterally. The voxels with connectivity to the seed voxel (crosshairs) appear to lie in similar locations to the task activation produced by word generation and to the locations with connectivity in figure 3

View larger version (24K): [in a new window]   FIG 5. A and B, Consecutive coronal images showing task activation for the visual task (A) and connectivity for the visual cortex (B). The task produces activation in the striate cortex region and in the posterior parietal lobes bilaterally. The voxels with connectivity to the seed voxel (crosshairs) appear to lie in similar locations in the striate cortex region and in the posterior parietal lobe

View larger version (14K): [in a new window]   FIG 6. Spectral decomposition of the average correlation coefficient for interregional connectivity in the motor cortex (same subject as in fig 1). Only frequency components between 0 and 0.05 Hz contribute significantly to the correlation coefficient

View larger version (12K): [in a new window]   FIG 7. Spectral decomposition of the average correlation coefficient for interregional connectivity in the auditory cortex (same subject as in fig 2). Only frequency components less than 0.05 Hz contribute significantly to the correlation coefficient

View larger version (13K): [in a new window]   FIG 8. Spectral decomposition of the average correlation coefficient for interregional connectivity in the prefrontal cortex (same subject as in fig 3). Only the same low frequency components contribute significantly to the correlation coefficient

View larger version (18K): [in a new window]   FIG 9. Spectral decomposition of the average correlation coefficient for interregional connectivity in the prefrontal cortex (same subject as in fig 4). Only the same low-frequency components contribute significantly to the correlation coefficient

View larger version (13K): [in a new window]   FIG 10. Spectral decomposition of the average correlation coefficient for interregional connectivity in the visual cortex (same subject as in fig 5). Only low-frequency components contribute significantly to the correlation coefficient

View larger version (21K): [in a new window]   FIG 11. Spectral decomposition of the average correlation coefficient from a seed voxel in the left jugular vein. Note the relative paucity of frequencies in the 0 to 0.05 Hz range, the spread over many frequencies, and the peak at 0.2 Hz

View larger version (23K): [in a new window]   FIG 12. Spectral decomposition of the average correlation coefficient using a seed voxel in the right middle cerebral artery. Low frequencies do not predominate. Peaks are present at multiple frequencies above 0.05 Hz

View larger version (18K): [in a new window]   FIG 13. Spectral decomposition of the average correlation coefficient using a seed voxel in the left ventricle. Frequencies from 0.025 to 0.075 predominate. Since no BOLD effect can be invoked in CSF, these frequencies represent likely aliased cardiac cycle effects