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Regional Differences and Metabolic Changes in Normal Aging of the Human Brain: Proton MR Spectroscopic Imaging Study

Emmanuelle Angeliea, Alain Bonmartina, Abdel Boudraaa, Pierre-Marie Gonnauda, Jean-Jacques Malleta and Dominique Sappey-MarinierGo,a

a From the Unité RMN (E.A., Al.B., D.S.-M.) and the Département de Neurologie (P.-M.G.), Centre Hospitalier Lyon-Sud, Pierre-Bénite, and GRISN (EA 640) (Ab.B., J.-J.M.), Université Claude Bernard, Lyon, France.



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  		FIG 1. MR images identify the position of the PRESS volumes centered at the centrum semiovale and temporal lobe.

A, Sagittal T1-weighted MR image shows the PRESS volume (large box) localized at the centrum semiovale.

B, Sagittal T1-weighted MR image shows the PRESS volume (large box) localized in the temporal lobe.

C, Axial T2-weighted MR image shows the PRESS volume (large box) localized at the centrum semiovale. For metabolite quantitation, 30 voxels were selected and registered on the corresponding MR spectroscopic images. Markers indicate the positions of individual voxels selected in the cortical (x) and semioval (o) regions.

D, Axial T2-weighted MR image shows the PRESS volume (large box) localized in the temporal lobe. For metabolite quantitation, 30 voxels were selected and registered on the corresponding MR spectroscopic images. Markers indicate the positions of individual voxels selected in the temporal (x) and hippocampal (o) regions.



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  		FIG 2. Spectroscopic images of NAA obtained from the brain of a young participant. Four representative 1H MR spectra (C1–C4) were selected from the voxels (voxels 1–4) in the cortical (C1), semioval (C2), hippocampal (C3), and temporal (C4) regions to illustrate the regional variations. The nominal size (0.8 x 0.8 x 2 cm3) of the individual voxels is shown on the MRS images.

A, Localized at the centrum semiovale.

B, Localized in the temporal lobe.



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  		FIG 3. Regression plots of %NAA, %Cr, and %Cho in the semioval region regarding age





Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X