Advanced

AJNR - American Journal of Neuroradiology

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kadota, T. Articles by Kuroda, C. Search for Related Content PubMed PubMed Citation Articles by Kadota, T. Articles by Kuroda, C.

Development and Aging of the Cerebrum: Assessment with Proton MR Spectroscopy

Tsuyoshi Kadota^a, Takashi Horinouchi^a and Chikazumi Kuroda^a

^a From the Department of Diagnostic Radiology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, Osaka 537-8511, Japan.

View larger version (87K): [in a new window]   FIG 1. A and B, Sagittal (A) and axial (B) MR images of a healthy 20-year-old woman show the outlines of the spectroscopic VOI and typical position of 12 voxels in the centrum semiovale. Six voxels were in bilateral anterior, middle, and posterior regions containing predominantly white matter (white open boxes) and six voxels were in bilateral mesial cortex with mostly mesial gray matter of the anterior, middle, and posterior regions (black open boxes), respectively. C, Proton spectra obtained in right middle white matter (white open box) are shown. NAA, Cho, and Cr peaks were quantified by applying gaussian curve fittings.

View larger version (39K): [in a new window]   FIG 2. A and B, Scatter plots and fitting curves of averaged NAA/Cho ratios as a function of age in white matter (A) and gray matter (B) of the centrum semiovale.

View larger version (75K): [in a new window]   FIG 3. A–F, Scatter plots and fitting curves for male and female NAA/Cho ratios as a function of age in anterior (A), middle (B), and posterior (C) white matter, and anterior (D), middle (E), and posterior (F) gray matter of the right (R) and left (L) centrum semiovale.

View larger version (39K): [in a new window]   FIG 3. Continued.