Advanced

AJNR - American Journal of Neuroradiology

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Nusbaum, A. O. Articles by Atlas, S. W. Search for Related Content PubMed PubMed Citation Articles by Nusbaum, A. O. Articles by Atlas, S. W.

Regional and Global Changes in Cerebral Diffusion with Normal Aging

Annette O. Nusbaum^a, Cheuk Y. Tang^a, Monte S. Buchsbaum^a, Tsei Chung Wei^a and Scott W. Atlas^,a

^a From the Departments of Radiology (A.O.N., C.Y.T., T.C.W., S.W.A.) and Psychiatry (C.Y.T., M.S.B.), Mount Sinai School of Medicine, New York, NY; and the Department of Radiology, Stanford University, Stanford, CA (S.W.A.).

View larger version (61K): [in a new window]   FIG 1. Statistically significant regions of decreased anisotropy with increasing age. Areas with significant anisotropic decrease with age are shown in blue to blue-white and were identified in the frontal white matter, genu and splenium of the corpus callosum, and parietal and occipital periventricular white matter. Correlation coefficients between RA and age are displayed for each pixel with the scale bar indicating the correlation coefficient from r = -0.55, P < .05 (blue) to the most negative correlation found, P < .0001 (blue-white). (Background is group mean, anatomically standardized, T1-weighted images at four slice locations.)

View larger version (59K): [in a new window]   FIG 2. Statistically significant regions of increased anisotropy with increasing age. Areas of significant diffusion anisotropic increase with age are shown in red-yellow and were identified in the posterior limb of the internal capsules bilaterally and diffusely at the periphery of the brain, notably at the brain-CSF interfaces (most likely artifactual). Correlation coefficients are displayed using a method similar to that in figure 1, with the correlation coefficients from r = .55, P < .05 (red) to the most positive correlation found, r = .90, P < .0001 (yellow). (Background is group mean, anatomically standardized, T1-weighted images at four slice locations.)

View larger version (20K): [in a new window]   FIG 3. Averaged ADC histograms for each group of subjects (defined by age), where the x axis represents the average ADC values and the y axis scales with the number of pixels at any given ADC value

View larger version (67K): [in a new window]   FIG 4. Average brain ADC (mean trace) versus subject's age, linear regression

View larger version (66K): [in a new window]   FIG 5. Peak height of ADC histogram versus subject's age, linear regression

View larger version (67K): [in a new window]   FIG 6. Skew of ADC histogram versus subject's age, linear regression

View larger version (66K): [in a new window]   FIG 7. Peak location of ADC histogram versus subject's age, linear regression