Proton MR Spectroscopy in Patients with Acute Temporal Lobe Seizures
Mauricio Castillo
,a,
J. Keith Smitha and
Lester Kwocka
a From the Department of Radiology, Section of Neuroradiology, CB 7510, University of North Carolina School of Medicine, Chapel Hill, NC 27599.
View larger version (14K):
[in a new window]
|
FIG 1. Proton MR spectroscopy in a patient with left hippocampal seizures and lactate.
A, Single-voxel MR spectrum (TE = 135) of the abnormal left hippocampus shows inverted peak with doublet configuration, corresponding to lactate (L). The relationship between NAA (N) and Cr (C) is normal. The NAA peak is normally lower in the hippocampi as compared with gray matter elsewhere.
B, Single-voxel MR spectrum of the right hippocampus shows no lactate.
| |
View larger version (49K):
[in a new window]
|
FIG 2. Proton MR spectroscopy in a patient with left hippocampal seizures and lipids/lactate. Single-voxel MR spectrum (TE = 135) shows mildly decreased NAA and the presence of lipids/lactate (LIP). The right hippocampus was normal
| |
View larger version (68K):
[in a new window]
|
FIG 3. Initial and follow-up proton MR spectroscopy in a patient with left hippocampal seizures.
A, Single-voxel MR spectrum (TE = 135) shows inverted doublet of lactate (L). The level of NAA (N) is normal.
B, The right hippocampus shows no lipids/lactate and a normal relationship between NAA (N) and Cr (C).
C, Study obtained 4 months after initial examination, with patient seizure-free, shows no significant lipids/lactate in the left hippocampus. Relative to the contralateral hippocampus, the level of NAA is slightly decreased with respect to Cr and Cho.
D, MR spectrum shows the right hippocampus to be normal.
| |
View larger version (10K):
[in a new window]
|
FIG 4. NAA/Cr ratios for hippocampi in healthy control subjects (Normal) and in patients with seizures at initial (Seizure) and follow-up (F/U Seizure) examinations
| |
AJNR - American Journal of Neuroradiology