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Blood Volume of Gliomas Determined by Double-Echo Dynamic Perfusion-Weighted MR Imaging: A Preliminary Study

Hidemasa Uematsua, Masayuki Maedaa, Norihiro Sadatoa, Tsuyoshi Matsudaa, Yoshiyuki Ishimoria, Yoshio Koshimotoa, Hirohiko Kimuraa, Hiroki Yamadaa, Yasutaka Kawamuraa, Yoshiharu Yonekuraa and Harumi Itoha

a From the Department of Radiology (H.U., Y.I., Y.Ko., H.K., H.Y., Y.Ka., H.I.) and the Biological Imaging Research Center (Y.Y.), Fukui Medical University, Fukui; the Department of Radiology, Mie University School of Medicine, Mie (M.M.); the Department of Cerebral Research, National Institute for Physiological Sciences, Aichi (N.S.); and the Application Research Department, Advanced Technology Center, GE Yokogawa Medical Systems Ltd, Tokyo (T.M.), Japan.



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  		FIG 1. Case 2: 54-year-old man with a GBM.

A, Time course of the {Delta}R2* values of the GBM and normal white matter. The {Delta}R2*T1C values of the GBM are represented by solid squares and its gamma-fitted curve by a thick line; {Delta}R2*T1U is represented by solid circles and its gamma-fitted curve a thin line. The {Delta}R2*T1C values of normal white matter are represented by solid triangles and its gamma-fitted curve by a dashed line.

B, A stereotactic biopsy was performed before the MR study. A transaxial section of a contrast-enhanced T1-weighted (333/10/3) spin-echo image is shown on the left, the corresponding VT1U map is in the middle, and the VT1C map is on the right. The GBM shows nonhomogeneously dense contrast enhancement in the left frontotemporal lobe. Note that blood volume of the tumor is much more prominent on the VT1C map (arrow) than on the VT1U map. The qualitative analysis was rated as 1 in this case. The VT1U/VT1C ratio is 0.41.



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  		FIG 2. Case 5: 37-year-old man with a GBM who had previously undergone surgical resection, irradiation, and chemotherapy for a GBM of the right frontal lobe. Recently, a recurrent tumor was found on follow-up CT studies. A transaxial section of a contrast-enhanced T1-weighted spin-echo MR image (333/10/3) is shown on the left, a corresponding VT1U map is in the middle, and the VT1C map is on the right. The recurrent GBM shows dense contrast enhancement in the right frontal lobe, extending to the corpus callosum. Small, enhanced foci are also depicted in the left frontal lobe. Note that the lesion in the corpus callosum is depicted as an area of hypervascular blood volume on the VT1C map (arrow), and the blood volume of this lesion is similar to that of gray matter on the VT1U map, indicating the tumor blood volume is underestimated on the VT1U map. The qualitative analysis was rated as 1 in this case. The VT1U/VT1C ratio is 0.64





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X