AJDRAJNR - American Journal of Neuroradiology

This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kikuchi, K.
Right arrow Articles by Ohue, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kikuchi, K.
Right arrow Articles by Ohue, S.

Measurement of Cerebral Hemodynamics with Perfusion-weighted MR Imaging: Comparison with Pre- and Post-acetazolamide 133Xe-SPECT in Occlusive Carotid Disease

Keiichi KikuchiGo,a, Kenya Murasea, Hitoshi Mikia, Takanori Kikuchia, Yoshifumi Sugawaraa, Teruhito Mochizukia, Junpei Ikezoea and Shiro Ohuea

a From the Departments of Radiology (K.K., K.M., H.M., T.K., Y.S., T.M., J.I.) and Neurological Surgery (S.O.), Ehime University School of Medicine, Ehime, Japan.



View larger version (32K):

[in a new window]
  		FIG 1. ROIs used for the analysis of cerebral perfusion. ROIs were placed on six regions in the brain parenchyma of each hemisphere. The ROIs were obtained from four slices on 133Xe-SPECT scans and from two to four slices from PWI images. ROI 1 corresponded to the left ACA territory, ROI 2 to the left ABZ territory, ROIs 3 and 4 to the left MCA territory, ROI 5 to the left PBZ territory, and ROI 6 to the left PCA territory. ROIs 7 through 12 corresponded to the same territories in the right hemisphere. The ROI setting was consistent between 133Xe-SPECT and PWI. Data from 10 regions were obtained for each patient



View larger version (48K):

[in a new window]
  		FIG 2. Example of PWI and 133Xe-SPECT studies in patient 7.

A, Comparison of the AIFs obtained from the ICA and MCA. Note that they vary slightly and that the AIF from the ICA is somewhat better than that from the MCA.

B, rCBF image generated from PWI (rCBF-PWI).

C, rCBV image generated from PWI (rCBV-PWI).

D, 133Xe-SPECT scan. Note that images generated from PWI were superior to 133Xe-SPECT scan in spatial resolution, and that rCBF and rCBV values in the deep brain structure can be evaluated on rCBF-PWI and rCBV-PWI images.



View larger version (25K):

[in a new window]
  		FIG 3. Relationship between the rCBF values obtained from 133Xe-SPECT (rCBF-SPECT) and those obtained PWI (rCBF-PWI). A significant correlation was found between them (r = .648, P < .0001, n = 78)



View larger version (23K):

[in a new window]
  		FIG 4. A–C, Box-and-whisker plot of rCBF-SPECT (A), rCBF-PWI (B), and rCBV-PWI (C) in the regions with severely decreased (% increase <= 0%), moderately decreased (0 < % increase <= 15%), and normal (15% < % increase) perfusion reserve. % increase was defined as [(post-rCBF) - (pre-rCBF)]/(pre-rCBF) x 100, where pre-rCBF and post-rCBF denote the CBF values before and after acetazolamide CBF as measured on 133Xe-SPECT scans, respectively. Boxes represent 25% to 70% range with bisecting lines showing medium values; horizontal lines represent 10% to 90% range; NS indicates not significant. Note that the regions with severely decreased perfusion reserve show significantly lower rCBF values on 133Xe-SPECT (A) and rCBF-PWI (B) studies than do those with moderately decreased or normal perfusion reserve. They also show significantly higher rCBV values on rCBV-PWI study (C) than do those with moderately decreased or normal perfusion reserve.





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X