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AJNR - American Journal of Neuroradiology

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Magnetization Transfer Ratio Histogram Analysis of Gray Matter in Relapsing-remitting Multiple Sclerosis

Yulin Ge^a, Robert I. Grossman^,a, Jayaram K. Udupa^a, James S. Babb^a, Dennis L. Kolson^a and Joseph C. McGowan^a

^a From the Departments of Radiology (Y.G., R.I.G., J.K.U., J.C.M.) and Neurology (D.L.K.), Hospital of the University of Pennsylvania and the Department of Biostatistics (J.S.B.), Fox Chase Cancer Center, Philadelphia, PA.

View larger version (131K): [in a new window]   FIG 1. Segmentation of gray matter results (right) and corresponding proton density– (left) and T2-weighted (middle) in control subjects (A) and patients (B). Note that the enlargement of the sulci attributable to brain atrophy could be seen on the T2-weighted image (B, middle) in MS patients, which might be due to the volume loss of white matter

View larger version (15K): [in a new window]   FIG 2. The average gray matter MTR histograms between 18 relapsing-remitting MS patients (solid line) and 18 age-matched control subjects (dotted line). Note the whole body of the histogram was shifted to the left in MS patients, although the peak height is similar with healthy individuals

View larger version (13K): [in a new window]   FIG 3. Regression analysis of relative frequency of gray matter MTR mode versus EDSS in relapsing-remitting MS patients. Dots are the relative frequencies of gray matter MTR mode (peak heights) for individual patients on EDSS. The line represents the predictive relative frequency of MTR mode with EDSS as a function. There was an inverse correlation (Spearman rank correlation, r = -0.65) between relative frequency of mode and EDSS

View larger version (14K): [in a new window]   FIG 4. Regression analysis of gray matter MTR mean values versus total T2 lesion volume (mm3) in relapsing-remitting MS patients. Dots are the mean MTR values for individual patients. The line represents the predictive mean MTR with total T2 lesion volume as a function. There was an inverse correlation (Pearson correlation coefficient, r = -0.55) between mean MTR of gray matter and T2 lesion volume