Advanced

AJNR - American Journal of Neuroradiology

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Park, S.-W. Articles by Park, Y. H. Search for Related Content PubMed PubMed Citation Articles by Park, S.-W. Articles by Park, Y. H.

Lateralizing Ability of Single-voxel Proton MR Spectroscopy in Hippocampal Sclerosis: Comparison with MR Imaging and Positron Emission Tomography

Sun-Won Park^a, Kee-Hyun Chang^,a, Hong-Dae Kim^a, In Chan Song^a, Dong Soo Lee^a, Sang Kun Lee^a, Chun-Kee Chung^a, In Kyu Yu^a, Moon Hee Han^a and Yang Hee Park^a

^a From the Departments of Radiology (S-W.P., K-H.C., H-D.K., I.K.Y., M.H.H.), Nuclear Medicine (D.S.L.), Neurology (S.K.L.), and Neurosurgery (C-K.C.), the Institute of Radiation Medicine (K-H.C., I.C.S., M.H.H.), and the Neuroscience Research Institute (K-H.C., D.S.L., S.K.L., C-K.C., M.H.H.), Seoul National University College of Medicine; and the National Police Hospital (Y.H.P.), Seoul, Korea.

View larger version (98K): [in a new window]   FIG 1. Concordance among MR imaging, MRS, and PET in right hippocampal sclerosis. Oblique coronal T2-weighted MR image (top row, middle) shows right hippocampal sclerosis (arrow), in concordance with PET scan (bottom row, middle), which shows decreased metabolism in right temporal lobe (arrow). The MR spectrum from the right hippocampus (Rt) shows marked decrease in NAA/Cho ratio (arrow). The MR spectrum from left hippocampus is normal (Lt)

View larger version (99K): [in a new window]   FIG 2. Discordant MRS with MR imaging and PET in left hippocampal sclerosis. Oblique coronal T2-weighted MR image (top row, middle) shows left hippocampal atrophy (arrow), in concordance with PET scan (bottom row, middle), which shows decreased metabolism in left temporal lobe (arrow). However, the MR spectrum from the left hippocampus (Lt) appears within normal range (false-negative finding), based on the abnormal criteria of an NAA/Cho ratio of 0.8 or less or an NAA/Cr ratio of 1.0 or less. The MR spectrum from the left hippocampus (Lt) shows a decrease in NAA/Cho and NAA/Cr ratios (arrow) on right side (Rt) (false-positive finding)

View larger version (105K): [in a new window]   FIG 3. Bilateral abnormality on MRS in left hippocampal sclerosis. Oblique coronal T2-weighted MR image (top row, middle) shows left hippocampal sclerosis with increased signal intensity (arrow), in concordance with PET scan (bottom row, middle), which shows decreased metabolism (arrow) in left temporal lobe. The MR spectra (Rt and Lt) show bilateral abnormalities (arrows), decreased NAA/Cho ratios bilaterally, and decreased NAA/Cr ratio on right side