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AJNR - American Journal of Neuroradiology

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Astrocytic Swelling in the Ipsilateral Substantia Nigra after Occlusion of the Middle Cerebral Artery in Rats

Makoto Nakane^,a, Akira Tamura^a, Naoyuki Miyasaka^a, Tsukasa Nagaoka^a and Toshihiko Kuroiwa^a

^a From the Department of Neurosurgery, Teikyo University School of Medicine (M.N., A.T.), Tokyo; and the Departments of Neurosurgery (T.N.), Obstetrics and Gynecology (N.M.), and Neuropathology, Medical Research Institute (T.K.), Tokyo Medical and Dental University, Tokyo, Japan.

View larger version (55K): [in a new window]   FIG 1. Representative MR images 4 days after MCA occlusion. A–C, The infarction is seen as an area of high signal intensity on diffusion-weighted image (A). The ipsilateral substantia nigra shows high signal intensity on T2-weighted (B) and diffusion-weighted (C) images (arrowhead)

View larger version (197K): [in a new window]   FIG 2. Light micrograph of the left substantia nigra pars reticulata shows perivascular enlargement (arrowheads) and intact neurons (arrows) (toluidine blue, original magnification x320)

View larger version (177K): [in a new window]   FIG 3. Electron micrograph of the left substantia nigra pars reticulata shows the blood vessel (arrowheads) surrounded by lucent swollen astrocytic end-feet. Bar = 1 µm