Imaging Findings in Rabies Encephalitis
Manasi Awasthia,
Hemant Parmar
,a,
Tufail Patankara and
Mauricio Castilloa
a From the Department of Radiology, King Edward VII Memorial Hospital, Mumbai, India (M.A., H.P.); the Manchester Radiology Training Scheme, University of Manchester, UK (T.P.); and the Department of Radiology, University of North Carolina, Chapel Hill (M.C.).
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FIG 1. Case 1: 6-year-old boy with generalized seizures and altered consciousness.
A–C, Plain (A) and contrast-enhanced (B and C) CT scans show nonenhancing bilateral basal ganglia hypodenstities. No other areas of altered CT attenuation were seen. There was no evidence of enhancement on administration of contrast material. No areas of altered attenuation are seen in the brain stem (C).
D, Photomicrograph with immunoflourescent staining of the corneal impression smear shows bright apple-green viral nucleocapsid antigen targeted by the virus-specific fluorescent-labeled antibodies and seen using fluorescein isothiocyanate filter.
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FIG 2. Case 2: 30-year-old man with altered consciousness and drowsiness.
A, Axial spin-echo T1-weighted MR image (600/15 [TR/TE]) shows hyperintensity in the globus pallidus and putamen bilaterally. Minimal hyperintensities are also seen in the thalamus bilaterally.
B, Axial spin-echo proton density–weighted MR image (2600/22) shows hyperintensities in the heads of the caudate nuclei bilaterally. Hyperintensities are also seen in the globus pallidus and putamen bilaterally (right more than the left).
C, MR image at the level of the brain stem shows no abnormal signal.
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FIG 3. Histopathologic section of the brain from a different case shows the presence of intracytoplasmic Negri bodies (arrow) in the cortical neuron (hemotoxylin-eosin, original magnification x400)
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