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AJNR - American Journal of Neuroradiology

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Scan-Rescan Variation of Measures Derived from Brain Magnetization Transfer Ratio Histograms Obtained in Healthy Volunteers by Use of a Semi-interleaved Magnetization Transfer Sequence

Matilde Inglese^a, Mark A. Horsfield^a and Massimo Filippi^,a

^a From the Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy (M.I., M.F.), and the Division of Medical Physics, University of Leicester, Leicester, UK (M.A.H.).

View larger version (33K): [in a new window]   FIG 1. Data collection scheme for the semiinterleaved MT sequence. For each image, k-space data are collected in three blocks. The first one third of the non-MT image (block labeled 1) is followed by the first one third of the MT image (block labeled 2). This is followed by acquisition of the second and third blocks of the two images (labeled 3 through 6) in this semiinterleaved fashion. For the first few lines of blocks 2 through 6, the macromolecular magnetization saturation is not in a steady state, leading to slightly lower MT values than for sequential acquisition, but the likelihood of misregistration between the non-MT and MT images is considerably reduced