Serial Angiography in an Elastase-induced Aneurysm Model in Rabbits: Evidence for Progressive Aneurysm Enlargement after Creation
Naomi H. Fujiwara
,a,
Harry J. Clofta,
William F. Marxa,
John G. Shorta,
Mary E. Jensena and
David F. Kallmesa
a From the Department of Radiology (N.H.F., W.F.M., J.G.S., M.E.J., D.F.K.), University of Virginia Health Services, Charlottesville, VA and the Department of Radiology, Emory University Hospital, Atlanta, GA.
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FIG 1.
Mean aneurysm width versus time after aneurysm creation. Control animals (no elastase) showed progressive decrease in width over time (open circles). Test animals (elastase injured) showed progressive increase in aneurysm width over time,  21 days after aneurysm creation (solid circles).
FIG 2. Mean aneurysm height versus time after creation. Control (no elastase) animals showed progressive decrease in height over time (open circles). Test animals (elastase injured) showed progressive increase in aneurysm height over time, 21 days after aneurysm creation (solid circles). Upper error bars for control animals at 3 and 7 days were removed to avoid confusion.
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FIG 3. Angiograms of control animal 3 (no elastase).
A, Anteroposterior view IV DSA obtained 3 days after surgery. There is a small, slitlike opening at the stump of the right CCA (straight arrow).
B, Anteroposterior view IV DSA obtained 4 weeks after surgery. There has been progressive decrease in the size of the stump of the CCA (curved arrow).
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FIG 4. Angiograms of test animal 1.
A, Anteroposterior view IV DSA obtained 3 days after creation of aneurysm at origin of right CCA. Brachiocephalic arteries are opacified, including the left CCA (curved arrow), right subclavian artery (open arrow), and "aneurysm cavity" (ie, the aneurysmal dilation of right CCA origin) (straight solid arrows). The aneurysm cavity measures 3.5 mm in width, in reference to the external sizing device.
B, Anteroposterior view IV DSA obtained 21 days after creation of aneurysm. The morphology of the aneurysm cavity has changed as compared with that seen on day 3 in that the aneurysm cavity is more bulbous in shape (arrows). The aneurysm cavity measures 5.4 mm in width.
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FIG 5. Angiograms of test animal 2.
A, Anteroposterior view IV DSA obtained 3 days after creation of aneurysm at origin of right CCA. Brachiocephalic arteries are opacified, including the left CCA (curved arrow), right subclavian artery (open arrow), and aneurysm cavity (straight solid arrows). The aneurysm cavity measures 2.8 mm in width.
B, Anteroposterior view IV DSA obtained 17 weeks after creation of aneurysm. The aneurysm cavity measures 4.0 mm in width (arrows).
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FIG 6. Angiograms of test animal 4.
A, Anteroposterior view IV DSA obtained 3 days after creation of aneurysm at origin of right CCA. Brachiocephalic arteries are opacified, including the left CCA (curved arrow), right subclavian artery (open arrow), and aneurysm cavity (straight solid arrows). The aneurysm cavity measures 4.0 mm in width.
B, Anteroposterior view IV DSA obtained 4 months after creation of aneurysm. The aneurysm cavity has markedly enlarged in size as compared with the earlier image, with the aneurysm cavity measuring 6.0 mm in width.
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