T2 Relaxation Measurements in X-linked Adrenoleukodystrophy Performed Using Dual-echo Fast Fluid-attenuated Inversion Recovery MR Imaging
Elias R. Melhem
,a,
Theodore F. Gotwalda,
Ryuta Itoha,
S. James Zinreicha and
Hugo W Mosera
a From the Department of Radiology and Radiological Sciences (T.F.G.), The Johns Hopkins Medical Institutions; the F.M. Kirby MR Research Center, Kennedy-Krieger Institute (E.R.M., R.I., S.J.Z.), The Johns Hopkins Medical Institutions; and the Department of Neurogenetics (H.W.M.), Kennedy-Krieger Institute, The Johns Hopkins Medical Institutions, Baltimore, MD.
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FIG 1. Images of a 13-year-old male patient with X-linked adrenoleukodystrophy.
A, Axial first echo fast FLAIR image (6000/58 [TR/first TEeff]; inversion time, 2000 ms).
B, Axial second echo fast FLAIR image (6000/160 [TR/second TEeff] inversion time, 2000 ms).
C, Axial first echo conventional spin-echo MR image (3000/30 [TR/first TE]).
D, Axial second echo conventional spin-echo MR images (3000/100 [TR/second TE]) of the brain, obtained at the level of the lateral ventricles, show symmetrical and confluent abnormal signal intensity in the deep white matter of the both parietooccipital lobes and splenium of the corpus callosum. The peripheral (arrowheads) and central (asterisks) zones are most distinct on the first echo fast-FLAIR image.
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FIG 2. Images of an 8-year-old male patient with X-linked adrenoleukodystrophy.
A, Axial view first echo fast-FLAIR image (6000/58 [TR/first TEeff]; inversion time, 2000 ms).
B, Axial view second echo fast-FLAIR image (6000/160 [TR/second TEeff]; inversion time, 2000 ms).
C, Corresponding T2 maps of the brain, obtained at the level of the lateral ventricles, show symmetrical and confluent abnormal signal intensity in the deep white matter of the both parietooccipital lobes. Note that regions of highest signal intensity on the T2 map (ie, highest T2 values) correspond to the central zone of low signal intensity on the first echo FLAIR image.
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