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AJNR - American Journal of Neuroradiology

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CT-guided Biopsy of Focal Lesions in Patients with Multiple Myeloma May Reveal New and More Aggressive Cytogenetic Abnormalities

Ramesh Avva^a, Rudy L. Vanhemert^a, Bart Barlogie^a, Nikhil Munshi^a and Edgardo J. Angtuaco^,a

^a From the Department of Radiology, Division of Neuroradiology (R.A., R.L.V., E.J.A.), and the Myeloma and Transplantation Research Center, Arkansas Cancer Research Center (B.B., N.M.), University of Arkansas for the Medical Sciences, Little Rock.

View larger version (97K): [in a new window]   FIG 1. Sacral plasmacytoma in a patient in the TT II trial. A, Coronal STIR T1-weighted image shows a large hyperintense plasmacytoma in the right sacral ala. B, CT-guided FNA of a large lytic lesion shows cytogenetic abnormalities, including chromosome 13 deletion

View larger version (86K): [in a new window]   FIG 2. T6 plasmacytoma of the posterior elements in a patient in the DTPACE trial. A, Sagittal STIR T1-weighted image shows a large hyperintense lesion involving the spinous process and right lamina. B, CT scan shows only a small lytic component, for which biopsy revealed chromosome 13 deletion.