Advanced

AJNR - American Journal of Neuroradiology

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Steen, R. G. Articles by Pivnick, E. K. Search for Related Content PubMed PubMed Citation Articles by Steen, R. G. Articles by Pivnick, E. K.

Prospective Evaluation of the Brain in Asymptomatic Children with Neurofibromatosis Type 1: Relationship of Macrocephaly to T1 Relaxation Changes and Structural Brain Abnormalities

R. Grant Steen^a, June S. Taylor^,a, James W. Langston^a, John O. Glass^a, Vickie R. Brewer^a, Wilburn E. Reddick^a, Roy Mages^a and Eniko K. Pivnick^a

^a From the Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN (R.G.S., J.S.T., J.W.L., J.O.G., W.E.R., R.M.); the Departments of Pediatrics (R.G.S., V.R.B., E.K.P.), Radiology (R.G.S., J.S.T. J.W.L.), Biomedical Engineering (R.G.S.), and Ophthalmology (E.K.P.), University of Tennessee School of Medicine, Memphis; the Center for Pediatric Neuropsychology, LeBonheur Children's Medical Center, Memphis (V.R.B.); and the Departments of Psychology (V.R.B.), Biomedical Engineering (W.E.R.), and Electrical Engineering (W.E.R.), University of Memphis, TN.

View larger version (82K): [in a new window]   FIG 1. A, T1-weighted sagittal midline image (266/6/3) in an 11-year old boy with NF-1 and macrocephaly shows where the measurements of midline structures were made (see Table 2). This boy had thickening of the corpus callosum and enlargement of the anteroposterior diameter of the pons and medulla. B, T2-weighted transverse image (3500/93/1) in an 8-year old girl shows bilateral lesions in the globus pallidus and tectum

View larger version (15K): [in a new window]   FIG 2. Scatterplot of quantitative tissue T1 in the nucleus pulvinarus versus FSIQ in children with NF-1 (r = .58; P = .012 by ANOVA)