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AJNR - American Journal of Neuroradiology

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Abnormal Magnetization Transfer Ratios in Normal-appearing White Matter on Conventional MR Images of Patients with Occlusive Cerebrovascular Disease

Hirotsugu Kado^,a, Hirohiko Kimura^a, Tatsuro Tsuchida^a, Yoshiharu Yonekura^a, Tomoo Tokime^a, Yasuhiko Tokuriki^a and Harumi Itoh^a

^a From the Department of Radiology (H.Ka., H.ki., T.Tsu., H.I.) and Biomedical Imaging Research Center (Y.Yo.), Fukui Medical University, Fukui; and Department of Neurosurgery (T.To., Y.To.), Fukui Red Cross Hospital, Fukui, Japan

View larger version (119K): [in a new window]   FIG 1. The location of selected ROIs. Four ROIs were selected in the lesional deep white matter and three in the lesional centrum semiovale. Although this figure shows that ROIs were placed only on MTR maps and CBF images, actually the same ROIs were selected on T2-weighted images and other PET scans (CMRO2 and OEF images). PET scans were registered to the MR images of each subject. Circular ROIs were placed in right and left symmetrical locations, so that the AI could be calculated

View larger version (17K): [in a new window]   FIG 2. 2D plot of MTR and rCMRO2 values with an AI from groups 0, 1, and 2. The correlation coefficient was .85 (P = .001)