Initial and Follow-up MR Imaging Findings in AIDS-Related Progressive Multifocal Leukoencephalopathy Treated with Highly Active Antiretroviral Therapy
Majda M. Thurnhera,
M. Judith Donovan Posta,
Armin Riegera,
Christina Kleibl-Popova,
Christian Loewea and
Erwin Schindlera
a From the Departments of Radiology (M.M.T., C.L., E.S.) and Dermatology (A.R., C.K-P.), University of Vienna, Vienna, Austria; and the Department of Radiology, University of Miami School of Medicine, Miami, FL (M.J.D.P.).
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FIG 1. Case 2: 32-year-old HIV-positive woman with PML and survival time exceeding 22 months.
A and B, Initial MR study, December 1998. Axial FLAIR-FSE (TR/TE = 10000/150, TI = 2600) image (A) shows high-signal-intensity lesion in the white matter of the right centrum semiovale (arrow). There is no mass effect. No enhancement was present on contrast-enhanced T1-weighted (550/20) image (B).
C and D, Follow-up MR study, January 1999 (1 month after initiation of HAART). FLAIR-FSE (10000/150, TI = 2600) image (C) shows progression of white matter abnormalities (arrow) with mass effect and compression of right ventricle. Increased hypoattenuation of the lesion was evident on T1-weighted (550/20) images (not shown). On contrast-enhanced T1-weighted (550/20) image (D), diffuse enhancement of white matter abnormalities is present (arrows).
E and F, Subsequent MR study, February 1999 (2 months after initiation of HAART). FLAIR-FSE (10000/150, TI = 2600) image (E) shows further progression of the high-signal-intensity lesions of white matter disease (asterisks). Slight enhancement is still present on contrast-enhanced T1-weighted (550/20) image (F). Note increased hypoattenuation of the lesions and regression of the mass effect. Continued on page 982
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FIG 1. Continued.
G and H, Further follow-up MR study, April 1999 (4 months after initiation of HAART). FLAIR-FSE (10000/150, TI = 2600) image (G) reveals regression of the white matter changes with partially present low signal (corresponding to areas of increased hypoattenuation on T1-weighted images). Note atrophic changes of the right hemisphere with widening of the ventricle (arrow). Further increase in hypointensity is evident on T1-weighted (550/20) image (H). Elongated hyperintense area is seen medial to the sylvian fissure, representing subacute hemorrhage (arrow). Enhancement was not present on contrast-enhanced T1-weighted image (not shown).
I and J, Follow-up MR examination, September 2000 (21 months after initiation of HAART). Axial FLAIR-FSE (7384/130, TI = 2100) image (I) and contrast-enhanced T1-weighted (8/2.7, flip angle = 10°) image (J) show atrophic changes in the right hemisphere with widening of the sulci and further ex-vacuo widening of the right ventricle (arrow). Note low signal on the FLAIR-FSE image, representing leukomalacia
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FIG 2. Case 4: 28-year-old man with AIDS who presented with psychomotor slowing and hemianopsia. Stereotactic biopsy revealed PML.
A–C, Initial MR study, March 1998. Axial FLAIR-FSE (10000/150, TI = 2600) image (A) shows scalloped, high-signal-intensity lesion in the parietooccipital white matter with extension to dorsal part of the corpus callosum on both sides (arrow). There is no mass effect. The lesion is hypointense on noncontrast T1-weighted SE (550/20) image (B). No enhancement is observed on contrast-enhanced T1-weighted SE (550/20) image (C).
D–F, Follow-up MR study, May 1998 (4 weeks after the start of HAART). FLAIR-FSE (10000/150, TI = 2600) image (D) shows progression of the white matter lesion (arrow) with involvement of the right parietal white matter and contralateral occipital white matter. Increased hypointensity is evident on noncontrast T1-weighted (550/20) image (E). Contrast-enhanced T1-weighted (550/20) image shows no enhancement (F)
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