Dynamic Contrast-enhanced T2*-weighted MR Imaging of Tumefactive Demyelinating Lesions
Soonmee Chaa,
Sean Piercea,
Edmond A. Knoppa,
Glyn Johnsona,
Clement Yanga,
Anthony Tona,
Andrew W. Litta and
David Zagzaga
a From the Departments of Radiology (S.C., S.P., E.A.K., G.J., C.Y., A.T., A.W.L.), Neurosurgery (E.A.K., D.Z.), and Pathology (D.Z.), Division of Neuropathology, and the Kaplan Cancer Center (E.A.K., D.Z.), New York University Medical Center, New York, NY.
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FIG 1. TDL in a 22-year-old woman.
A, Contrast-enhanced T1-weighted image (600/14/1) shows a well-circumscribed solidly enhancing mass in the right frontal lobe.
B, Fluid-attenuated inversion recovery image (9000/110/1) shows a mild degree of signal abnormality around the lesion.
C, Color overlay of rCBV map shows no evidence of increased blood volume.
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FIG 2. Glioblastoma multiforme in a 63-year-old woman.
A, Contrast-enhanced T1-weighted image (600/14/1) shows a well-circumscribed mass in the left frontal lobe.
B, T2-weighted image (3400/119/1) shows minimal edema and mass effect.
C, Color overlay of rCBV map shows marked increase in blood volume.
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FIG 3. TDL in a 37-year-old man.
A, T2-weighted image (3400/119/1) shows a large hyperintense mass lesion in the right parietal lobe. There are no visible flow voids within the lesion.
B, Unenhanced T1-weighted image (600/14/1) shows hypointense signal of the lesion.
C, Contrast-enhanced T1-weighted image (600/14/1) shows heterogeneous enhancement of the medial aspect of the lesion in a concentric pattern.
D, Dynamic T2*-weighted image (1000/54/1) obtained before IV administration of contrast agent.
E, Dynamic T2*-weighted image (1000/54/1) obtained during IV administration of contrast agent shows several periventricular, linear vessel-like structures (arrows) running through the center of the lesion near a dilated subependymal vein. The dominant lesion itself shows no signal loss.
F, Dynamic T2*-weighted image (1000/54/1) obtained 50 s after IV administration of contrast agent shows return of brain signal to baseline, with residual signal loss within the aforementioned linear vessel-like structures.
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