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AJNR - American Journal of Neuroradiology

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Normalization of Cerebral Volumes by Use of Intracranial Volume: Implications for Longitudinal Quantitative MR Imaging

Jennifer L. Whitwell^a, William R. Crum^a, Hilary C. Watt^a and Nick C. Fox^a

^a From the Dementia Research Group, Institute of Neurology, London, UK.

View larger version (65K): [in a new window]   FIG 1. T1-weighted MR images with sagittal and axial views. The intensity windowing is as used for segmentation. The TIV is calculated by summation and linear interpolation of the segmented axial slices. A, The total intracranial area is shown on one axial section. B, The axial sections used to sample the total intracranial volume are marked on the sagittal view.

View larger version (23K): [in a new window]   FIG 2. The relationships between TIV and age (A), brain volume and age (B), and normalized brain volume and age (C), in healthy controls

View larger version (16K): [in a new window]   FIG 3. Brain volumes and normalized brain volumes in male (M) and female (F) controls with group averages marked, showing a reduction in sex-dependent differences after TIV normalization.FIG 4. Comparison of TIV measurements from T1- and T2-weighted MR images in five controls and five AD patients.FIG 5. Serial T1-weighted TIV measurements in five controls and five AD patients

View larger version (23K): [in a new window]   FIG 6. Serial TIV and brain volumes in an at-risk patient who remained well (A) and an at-risk patient who developed AD (B), compared with normalized brain volumes from serial images in both of the patients at risk (C)