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AJNR - American Journal of Neuroradiology

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Xenon-Induced Flow Activation in Patients with Cerebral Insult Who Undergo Xenon-Enhanced CT Blood Flow Studies

Peter Horn^a, Peter Vajkoczy^a, Claudius Thomé^a, Elke Muench^a, Lothar Schilling^a and Peter Schmiedek^a

^a From the Departments of Neurosurgery (P.H., P.V., C.T., L.S., P.S.) and Anesthesiology and Intensive Care (E.M.), University Hospital Mannheim, Faculty of Clinical Medicine, University Heidelberg, Mannheim, Germany.

View larger version (116K): [in a new window]   FIG 1. sXe-enhanced CT blood flow study in a patient with severe head injury. Left, anatomic reference section (arrow indicates tip of TD-rCBF probe); right, corresponding rCBF (mL/100 g per minute) image shows severe right hemispheric hypoperfusion

View larger version (17K): [in a new window]   FIG 2. Graph shows an original TD-rCBF recording obtained during a 30% sXe/CT blood flow study in a patient with head injury. Baseline (BAS): preinhalation TD-rCBF recording (duration, 42 seconds); wash-in (WI): TD-rCBF during sXe inhalation (duration, 270 seconds)

View larger version (13K): [in a new window]   FIG 3. Relative changes (in %) in baseline values in TD-rCBF due to sXe inhalation as seen in 35 blood flow studies. Solid circles represent individual changes in TD-rCBF at various time periods; open circles depict mean changes in TD-rCBF as compared with baseline. BAS indicates baseline; WI % represents seven periods, each of 38 seconds' duration, of sXe inhalation

View larger version (17K): [in a new window]   FIG 4. Time course of arterial sXe concentration (open circles) and sXe-induced flow activation (solid circles). The x-axis displays relative values of end-tidal sXe concentration and TD-rCBF, respectively, with each parameter expressed in percentage of maximum response observed