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AJNR - American Journal of Neuroradiology

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An Automated Technique for Measuring Hippocampal Volumes from MR Imaging Studies

Karen M. Gosche^a, James A. Mortimer^a, Charles D. Smith^a, William R. Markesbery^a and David A. Snowdon^a

^a From the Institute on Aging (K.M.G., J.A.M.), University of South Florida, Tampa; and the Departments of Neurology (C.D.S.), Pathology and Neurology (W.R.M.), and Preventive Medicine (D.A.S.), College of Medicine, University of Kentucky, Lexington.

View larger version (78K): [in a new window]   FIG 1. Coronal MP-RAGE (11.4/4.4, 8° flip angle) images from a single participant. A, Hippocampi manually traced. B, Pixels identified with the algorithm as belonging to the hippocampi (bright white pixels).

View larger version (19K): [in a new window]   FIG 2. Left hippocampal volume obtained from KGMAP plotted against Braak AD pathologic stage in 51 participants from the Nun Study. Data in five individuals with a dementia other than AD were omitted from the plot. Values shown are mean ± standard error.