Reliability of Functional MR Imaging with Word-Generation Tasks for Mapping Broca's Area
John H. Brannena,
Behnam Badiea,
Chad H. Moritza,
Michelle Quigleya,
M. Elizabeth Meyeranda and
Victor M. Haughtona
a From the Departments of Radiology (J.H.B., C.H.M., V.M.H.), Neurosurgery (B.B.), and Medical Physics (M.Q., M.E.M.), University of Wisconsin, Madison.
View larger version (66K):
[in a new window]
|
FIG 1. Sagittal (top right), axial (left), and coronal (bottom right) fMR images in patients performing word-generation tasks.
A, Activation is evident in the pars triangularis and pars opercularis of the left inferior frontal gyrus (Brodmann areas 44 and 45) in a patient performing an LWG task.
B, Activation also is evident in Brodmann areas 44 and 45 in a patient with an arteriovenous malformation in the right hemisphere who is performing an LWG task.
C, Activation appears in Brodmann areas 9 and 46 in a patient with a tumor involving the inferior left frontal lobe who is performing a CWG task.
| |
View larger version (85K):
[in a new window]
|
FIG 2. Sagittal (top right), axial (left), and coronal (bottom right) fMR images in a patient with a large left frontal tumor who is performing an LWG task. Activation is identified primarily in the right inferior frontal gyrus (Brodmann area 45)
| |
View larger version (79K):
[in a new window]
|
FIG 3. Sagittal (top right), axial (left), and coronal (bottom right) activation images in two iterations of an LWG task.
A and B, Patient with a left frontal tumor. Activation occurs in the same gyri between iterations, although with slightly different patterns.
C and D, Patient with a left frontal tumor and right hemispheric activation.
| |
View larger version (77K):
[in a new window]
|
FIG 4. Coronal fMR imaging images of two iterations of an LWG task in a patient with a left middle cerebral arteriovenous malformation.
A, Activation in the first iteration.
B, Activation in the second iteration, showing similar activation compared with A.
C, Intersect map shows the voxels activated in the two iterations. The proportion of voxels in the intersect map compared with the average number of voxels in A and B (the CR) is 45%.
| |
View larger version (47K):
[in a new window]
|
FIG 5. Sagittal (top right), axial (left), and coronal (bottom right) projections in a patient with a right frontal tumor.
A, Activation from a CWG task.
B, Activation from an LWG task.
| |
View larger version (67K):
[in a new window]
|
FIG 6. Coronal images in a patient with a right frontoparietal arteriovenous malformation.
A, Activation from an AWG task
B, Activation from a CWG task. The activation patterns from the two variations of the word-generation task are similar.
C, Intersect map shows the voxels activated by both versions of the task. The CR was 52%.
| |
View larger version (66K):
[in a new window]
|
FIG 7. Comparison of intraoperative localization of speech function (ECS) and activation from the word-generation task (fMR imaging) in a patient with a left frontal-lobe glioma. Both activation and intraoperative localization of the speech mapping were classified as belonging to Brodmann areas 44 and 45. M indicates motor cortex; S, speech areas; T, tumor
| |
AJNR - American Journal of Neuroradiology