Oversizing of Self-Expanding Stents: Influence on the Development of Neointimal Hyperplasia of the Carotid Artery in a Canine Model
Eberhard C. Kirscha,b,
Mark S. Khangureb,
Philip Morlingc,
Terry J. Yorkd and
William McAuliffeb
a Department of Neuroradiology, University Hospital Basel, Switzerland
b Interventional Neuroradiology Unit, Department of Diagnostic and Interventional Radiology, Royal Perth Hospital, Australia
c Department of Neuropathology, Royal Perth Hospital, Australia
d Research Centre, Royal Perth Hospital, Australia
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FIG 1. Unsubtracted (left) and subtracted (right) digital angiograms show the stents in the right CCA after implantation.
A, The normal-sized stent (6 mm) is implanted in the distal position (arrows); the oversized stent (10 mm), in the proximal position (arrowheads).
B, Control angiograms of a distally implanted stent obtained after 4 months show no obvious luminal narrowing (arrows). Note the partially depicted proximal stent (arrowheads) in these magnified views.
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FIG 2. Light microscopic image of a representative transverse section (thickness, approximately 50 µm) through a stent shows a smooth and asymmetric, developed neointima in this CCA segment (arrowheads). Note that the stent wires were left in place (hematoxylin-eosin, original magnification x10).
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FIG 3. Graph shows the amounts of neointimal hyperplasia with normal-sized (distal position; size, 6–7 mm) and oversized (proximal position; size, 10 mm) stents in the CCA. N indicates the number of sections.
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FIG 4. Graph shows the mean neointimal thickness with the 24 stents, when normal-sized (distal position; size, 6–7 mm) and oversized (proximal position; size 10 mm) stents are compared. Data are a summary of that of all stent types studied. N indicates number of sections.
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