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AJNR - American Journal of Neuroradiology

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Comparison of Gadobenate Dimeglumine and Gadopentetate Dimeglumine: A Study of MR Imaging and Inductively Coupled Plasma Atomic Emission Spectroscopy in Rat Brain Tumors

Tian Zhang^a, Akira Matsumura^a, Tetsuya Yamamoto^a, Fumiyo Yoshida^a, Tadao Nose^a and Nobuhiro Shimojo^b

^a Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
^b Department of Environmental Medicine, Institute of Community Medicine, University of Tsukuba, Ibaraki, Japan

View larger version (69K): [in a new window]   FIG 1. Serial T1-weighted spin-echo MR images (514/28) obtained before and at 5 minutes, 30 minutes, 1 hour, and 2 hours after contrast agent administration. A–E, Gd-BOPTA was the contrast agent used. F–J, Gd-DTPA was the contrast agent used.

View larger version (19K): [in a new window]   FIG 2. L/B time profiles after IV administration of 0.1 mmol/kg of Gd-BOPTA and Gd-DTPA during T1-weighted imaging (514/28) at 2.4 T. Data are mean ± SD of six animals.

View larger version (29K): [in a new window]   FIG 3. Graphic representation of the gadolinium concentration in brain tissue in rats that received Gd-BOPTA. (Gd indicates gadolinium; BT, brain tumor; PT, peritumoral tissue; NB, normal brain.)

View larger version (29K): [in a new window]   FIG 4. Graphic representation of gadolinium concentration in brain tissue in rats that received Gd-DTPA.

View larger version (29K): [in a new window]   FIG 5. Graphic comparison of BT/NB with Gd-BOPTA versus that of Gd-DTPA.