MR Evaluation in Patients with Isolated Anosmia Since Birth or Early Childhood
Nasreddin D. Abolmaalia,c,
Volker Hietscholda,
Thomas J. Voglc,
Karl-Bernd Hüttenbrinkb and
Thomas Hummelb
a Department of Radiology, University of Dresden, Medical School, Dresden, Germany
b Department of Otorhinolaryngology, University of Dresden, Medical School, Dresden, Germany
c Department of Radiology of the University of Frankfurt, Frankfurt/Main, Germany
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FIG 1. Transverse reformation of a 3D data set of an MP-RAGE image. The eyeballs and olfactory bulbs are visible. The coronal plane indicates position of the plane of the PPTE. Note that in normosmic subjects with normal olfactory bulb, this plane cuts through the olfactory bulb.
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FIG 2. Coronal T1-weighted SE image in the PPTE in a healthy subject. Note visualization of the olfactory bulbs and normal development of the olfactory sulci.
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FIG 3. Coronal T1-weighted SE image in the PPTE in a patient with bilateral aplasia of the olfactory bulb, visible olfactory tracts (arrowheads), and slightly flattened olfactory sulci. Note partial volume effect of the right eyeball.
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FIG 4. Coronal T1-weighted SE image in the PPTE in a patient with absent olfactory tracts and sulci. Note partial volume effects of both eyeballs.
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FIG 5. Patient with olfactory tract present only on the right.
A, Coronal T1-weighted SE dorsal image in the PPTE. Olfactory tract is visible on the right (arrowhead). There is accordingly different development of the olfactory sulcus, as shown in B.
B, Transverse reformation of a 3D data set of an MP-RAGE image in the same patient. Olfactory tract on the left is absent; olfactory tract on the right is visible. Accordingly the olfactory sulcus is shorter (arrowhead) on the left where the olfactory tract is not detectable. Note exact transverse reformation as identified by symmetrical display of periorbital fat and the middle cerebral arteries.
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FIG 6. Olfactory sulcus (OS) depth in PPTE in patients with IA compared with that in healthy controls (means, SEM). Only olfactory sulcus depths greater than 0 were taken into consideration. The olfactory sulcus was significantly deeper on the right than on the left.
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FIG 7. Olfactory sulcus (OS) depth in the PPTE in IA patients with visible olfactory tracts (VOT) and in those with nonvisible olfactory tracts (NOT). There is no overlap between the two groups in terms of olfactory sulcus depth.
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