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MR Analysis of the Substantia Innominata in Normal Aging, Alzheimer Disease, and Other Types of Dementia

Haruo Hanyua, Tetsuichi Asanoa, Hirofumi Sakuraia, Yuriko Tanakaa, Masaru Takasakia and Kimihiko Abeb

a Department of Geriatric Medicine, Tokyo Medical University
b Department of Radiology, Tokyo Medical University



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  		FIG 1. Plot shows the correlation between age and thickness of the substantia innominata in control subjects. The thickness of the substantia innominata significantly decreased with normal aging (y = 3.576 - 0.013x, r = -.86, P < .0001).



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  		FIG 2. Plots show a significant correlation between MMSE scores and thickness of the substantia innominata in patients with AD but not in those with non-AD dementia. NS = not significant (P > .05).



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  		FIG 3. Coronal T2-weighted MR images (3000/100/3; section thickness, 3 mm; intersection gap, 0.9 mm; matrix, 256 x 231; field of view, 20 cm) shows the substantia innominata in five subjects (arrows, A–E).

A, Image in a 37-year-old healthy female control subject.

B, Image in a 70-year-old healthy male control subject shows thinning of the substantia innominata.

C, Image in a 67-year-old man with AD shows prominent atrophy of the substantia innominata.

D, Image in a 74-year-old man with vascular dementia shows prominent atrophy of the substantia innominata.

E, Image in a 64-year-old woman with frontotemporal dementia shows prominent atrophy of the substantia innominata.





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X