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AJNR - American Journal of Neuroradiology

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Radial Width of the Temporal Horn: A Sensitive Measure in Alzheimer Disease

Giovanni B. Frisoni^a, Cristina Geroldi^a,b, Alberto Beltramello^c, Angelo Bianchetti^d, Giuliano Binetti^b, Giovanni Bordiga^e, Charles DeCarli^f, Mikko P. Laakso^g,h,i, Hilkka Soininen^g,i, Cristina Testa^a, Orazio Zanetti^b and Marco Trabucchi^a,b

^a Laboratory of Epidemiology and Neuroimaging IRCCS San Giovanni di Dio-FBF, Brescia, Italy
^b Alzheimer’s Unit, IRCCS San Giovanni di Dio-FBF, Brescia, Italy
^c Service of Neuroradiology, Ospedale Maggiore, Verona, Italy
^d Department of Internal Medicine Ancelle della Carità Hospital, Cremona, Italy
^e Service of Radiology, Ancelle della Carità Hospital, Cremona, Italy
^f Alzheimer Disease Center, Kansas University Medical Center, Kansas City, USA
^g Department of Neurology, Kuopio University Hospital, Finland
^h Department of Clinical Radiology, Kuopio University Hospital, Finland
ⁱ Department of Neuroscience and Neurology, University of Kuopio, Finland

View larger version (97K): [in a new window]   FIG 1. Gross pathologic coronal (A) and axial (B) images showing the 2-mm section where the rWTH should be measured. Note.—Am indicates amygdala; hip, hippocampus. Bar = 10 mm. Adapted from Duvernoy, 1998 (54).

View larger version (154K): [in a new window]   FIG 2. CT scans chosen for rWTH measures. Represented are eight contiguous 2-mm-thick sections spanning the whole caudal-to-rostral extension of the temporal horns of a patient with AD. The scans in which the right and left horns can be appreciated in their full length are C and D, and these are chosen for the measurements. Parallel lines are drawn tangentially to the tip of the temporal horns where the width is maximum (arrows).

View larger version (27K): [in a new window]   FIG 3. Known-group validity of CT- (left) and MR-based (right) rWTH measures compared with that of other CT- and MR-based linear and volumetric measures of MTL atrophy in patients with AD (open circles) and control subjects (solid circles). Solid lines represent regression lines of the measures on age in control subjects. Dotted lines represent age-specific cutoffs that correctly classify 95% of control subjects.