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AJNR - American Journal of Neuroradiology

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Quantitative Functional MR Imaging of the Visual Cortex at 1.5 T as a Function of Luminance Contrast in Healthy Volunteers and Patients with Multiple Sclerosis

Scott H. Faro^a,d, Feroze B. Mohamed^a,d, Joseph I. Tracy^c,d, Robert M. Elfont^b, Alexander B. Pinus^a,d, Fred D. Lublin^e, Robert A. Koenigsberg^a, Cheng Y. Chen^f and Fong Y. Tsai^g

^a Department of Radiological Sciences, MCP Hahnemann University, Philadelphia, PA
^b Department of Neurology, MCP Hahnemann University, Philadelphia, PA
^c Department of Neurology, Thomas Jefferson University, School of Medicine, Philadelphia, PA
^d School of Biomedical Engineering and Health Sciences, Drexel University, Philadelphia, PA
^e Department of Neurology, Mount Sinai School of Medicine, New York, NY
^f Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan
^g Department of Radiological Sciences, University of California, Irvine, CA

View larger version (18K): [in a new window]   FIG 1. Line graph shows the number of activated voxels with graded increase in luminance contrast in healthy volunteers (controls) and patients with MS and a history of optic neuritis (MS with ON).

View larger version (10K): [in a new window]   FIG 2. Composite, axial T1-weighted image and fMR imaging activation map at the level of the primary visual cortex in a healthy volunteer at three luminance contrast levels: (A) lowest (baseline), (B) intermediate, (C) highest. Activation in the ROI, which represents the primary visual cortex within the medial portion of the occipital lobes (arrow, C), is shown in red and yellow, with yellow corresponding to the relatively more significantly activated voxels.

View larger version (11K): [in a new window]   FIG 3. Composite, axial T1-weighted image and fMR imaging activation map at the level of the primary visual cortex in a patient with MS at three luminance contrast levels: (A) lowest (baseline), (B) intermediate, (C) highest. Activation in the primary visual cortex is shown in red and yellow. There is low-level fMR imaging activation in A, no significant change in activation in B, and prominent activation in C.