Laryngeal Neurofibroma Associated with Neurofibromatosis Type 2
Mutlu Cihangiroglua,
Saim Yilmaze,
Cahide Topsakalb,
Uzeyir Gokc,
Baki Altinsoya and
Bengu Cobanoglud
a Department of Radiology, Firat University School of Medicine, Elaz
g, Turkey
b Department of Neurosurgery, Firat University School of Medicine, Elazg, Turkey
c Department of ENT, Firat University School of Medicine, Elazg, Turkey
d Department of Pathology, Firat University School of Medicine, Elazg, Turkey
e Department of Radiology, Akdeniz University School of Medicine, Antalya, Turkey
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FIG 1. Images from the case of a 32-year-old woman who presented with progressive hoarseness and dysphonia.
A, Endoscopic examination shows an oval mass in the supraglottic area adjacent to the epiglottis (arrow).
B, Contrast-enhanced CT scan shows a slightly hypoattenuated mass (arrow) within the left supraglottic area extending to the left aryepiglottic fold.
C, Axial view T1-weighted (600/25 [TR/TE]) MR image reveals a hypointense mass (large arrow) with a slightly hyperintense periphery as compared with the center (small arrow).
D, Axial view T2-weighted (4000/117) MR image reveals a hyperintense mass (large arrow) with a slightly hypointense center as compared with the periphery (small arrow) in the same localization as that shown in B.
E, Axial view contrast-enhanced T1-weighted MR image shows diffuse enhancement of the tumor (arrow) within left supraglottic area.
F, Axial view contrast-enhanced T1-weighted image reveals densely enhanced bilateral vestibular schwannomas (arrows) at both cerebellopontine angles.
G, Sagittal viewT1-weighted contrast-enhanced image confirms the intramedullary location of contrast-enhancing tumors (arrows) within the cervical and thoracic spine.
H, Histopathologic specimen from the laryngeal mass shows the tumor composed of neuronal fascicles and bundles within fibrous stroma, which is consistent with neurofibroma.
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