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AJNR - American Journal of Neuroradiology

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Does Streaming Affect the Cerebral Distribution of Infraophthalmic Intracarotid Chemotherapy?

Ronit Agid^a, Rina Rubinstein^b, Tali Siegal^c, Hava Lester^b, Felix Bokstein^c, Roland Chisin^b and John M. Gomori^a

^a Department of Radiology, Hadassah Hebrew University Hospital, Jerusalem, Israel
^b Department of Nuclear Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel
^c the Neurooncology Center, Hadassah Hebrew University Hospital, Jerusalem, Israel

View larger version (77K): [in a new window]   FIG 1. A and B, Registered and normalized 99mTc-HMPAO images at the two injection rates in two different patients (A and B) in coronal (top) and axial (bottom) planes. For each patient, the images on the left are after a rapid bolus injection and those on the right are after slow continuous injection. There is no visible difference between the two rates of injection, with the exception of minimal cross-flow to the contralateral frontal area on the bolus injection images in the second patient (B).

View larger version (142K): [in a new window]   FIG 2. A selection of subtracted and normalized axial 99mTc-HMPAO SPECT images of the patient in Fig 1A highlights a subtle increased distribution of radionuclide in the occipital region. This is due to increased cross-flow from the carotid to the posterior circulation in the rapid bolus injection.