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Dynamic Contrast-Enhanced T2*-Weighted MR Imaging of Gliomatosis Cerebri

Stanley Yanga, Stephan Wetzela and Soonmee Chaa

a Department of Radiology, New York University Medical Center, NY



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  		FIG 1. Images in a 35-year-old woman with pathologically confirmed gliomatosis cerebri.

Left, T2-weighted (3400/119) MR image demonstrates diffuse bilateral frontal signal intensity abnormality.

Middle, Contrast-enhanced axial T1-weighted (600/14) image demonstrates no evidence of contrast enhancement.

Right, Color overlay rCBV map demonstrates no evidence of increased perfusion in the region of signal intensity abnormality on the T2-weighted image.



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  		FIG 2. Images in a 42-year-old man with pathologically confirmed gliomatosis cerebri.

Left, T2-weighted (3400/119) MR image demonstrates a region of signal intensity abnormality in the right periventricular white matter.

Middle, Contrast-enhanced axial T1-weighted (600/14) image demonstrates subtle evidence of contrast enhancement.

Right, Color overlay rCBV map reveals that the areas corresponding to signal intensity abnormality on the T2-weighted image do not demonstrate increased perfusion.



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  		FIG 3. High-power view of histopathologic section of gliomatosis cerebri (hematoxylin-eosin with Luxol fast-blue stain, original magnification x200). There are moderately pleomorphic glial cells in a diffusely infiltrating pattern with relative preservation of underlying cytoarchitecture. No evidence of vascular proliferation or necrosis is seen. A small collapsed vascular structure (arrow) is noted.



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  		FIG 4. Findings in a 21-year-old woman with gliomatosis cerebri.

A, Axial fluid-attenuated inversion recovery (9000/110) image with localizer (box).

B, Corresponding spectrum (chemical shift imaging, PRESS, 1500/144) reveals elevated Cho/Cr and depressed NAA/Cr ratios.





Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X