Primary Sellar Lymphoma: Radiologic and Pathologic Findings in Two Patients
Timothy J. Kaufmanna,
M. Beatriz S. Lopesb,
Edward R. Laws, Jrc and
Maurice H. Lippera
a Department of Radiology, University of Virginia Health System, Charlottesville
b Department of Pathology (Neuropathology) University of Virginia Health System, Charlottesville
c Department of Neurosurgery, University of Virginia Health System, Charlottesville
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FIG 1. Case 1. Coronal T1-weighted (TR/TE, 500/20) MR images of the sellar region depict a large, heterogeneously enhancing sellar mass.
A, Nonenhanced image.
B, Gadolinium-enhanced image.
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FIG 2. Case 1. Photomicrographs.
A, Large cells with nuclei display prominent nucleoli that diffusely infiltrate the pituitary gland (hematoxylin-eosin, original magnification x200).
B, The lymphoma cells are reactive for LCA and stain darkly, in contrast with the normal entrapped pituitary cells (arrowheads) (CD45 immunohistochemical stain, original magnification x100).
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FIG 3. Case 2. T1-weighted MR images of the sellar region.
A, Coronal image (600/15) depicts a heterogeneously enhancing sellar mass.
B, More anterior coronal section (600/15) depicts invasion of the right sphenoid sinus (white arrows) and cavernous sinus (black arrow).
C, Sagittal gadolinium-enhanced image (500/16) depicts two large portions of the sellar and parasellar mass (arrows).
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FIG 4. Case 2. Photomicrographs.
A, Highly anaplastic malignant lymphoma with numerous mitotic figures (hematoxylin-eosin, original magnification x200).
B, Tumor cells express the B-cell marker L26 (CD20) and show dark membrane staining (CD45 immunohistochemical stain, original magnification x100).
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