Quantitative Measurement of Regional Cerebral Blood Flow with Flow-Sensitive Alternating Inversion Recovery Imaging: Comparison with [Iodine 123]-Iodoamphetamin Single Photon Emission CT
Ali Syed Arbaba,
Shigeki Aokia,
Keiji Toyamaa,
Nobuhiko Miyazawab,
Hiroshi Kumagaia,
Takako Umedaa,
Takao Araia,
Tsutomu Arakia,
Hiroyuki Kabasawac and
Yoshiyuki Takahashic
a Department of Radiology Yamanashi Medical University, Yamanashi
b Department of Neurosurgery Yamanashi Medical University, Yamanashi
c Department of GE-YMS Tokyo, Japan
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FIG 1. Composite ROC curves and Az values of the areas under the curves for the detection of abnormal segments on FAIR images obtained with different TIs show no significant difference among the Az values. TPF indicates true-positive fraction; FPF, false-positive fraction.
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FIG 2. 123I-IMP images in a representative case show normal perfusion. Although relatively decreased perfusion is seen at the left parietal-occipital region in A, quantitative analysis showed flow of more than 30 mL/100 g/min, with markedly increased flow after acetazolamide administration. Note similar cerebral blood flow depictions on both pre- and post-acetazolamide FAIR images.
A, Pre-acetazolamide 123I-IMP image.
B, Pre-acetazolamide FAIR image obtained with a TI of 1200 milliseconds.
C, Pre-acetazolamide FAIR image obtained with a TI of 1400 milliseconds.
D, Post-acetazolamide 123I-IMP image.
E, Post-acetazolamide FAIR image obtained with a TI of 1200 milliseconds.
F, Post-acetazolamide FAIR image obtained with a TI of 1400 milliseconds.
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FIG 3. Images in a patient with right middle cerebral artery occlusion. Note the linear high-signal intensity areas (arrows) along the major sulci at right temporoparietal regions; these may represent collateral flow or vessels with notably delayed flow.
A, Pre-acetazolamide 123I-IMP image.
B, Pre-acetazolamide FAIR image obtained with a TI of 1200 milliseconds.
C, Pre-acetazolamide FAIR image obtained with a TI of 1400 milliseconds.
D, Post-acetazolamide 123I-IMP image.
E, Post-acetazolamide FAIR image obtained with a TI of 1200 milliseconds.
F, Post-acetazolamide FAIR image obtained with a TI of 1400 milliseconds.
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FIG 4. Regression plots of rCBF values measured on pre-acetazolamide (-pre) and post-acetazolamide (-post) 123I-IMP and FAIR images. All plots show a significant correlation between 123I-IMP and FAIR results. A better correlation coefficient is observed between the findings on pre-acetazolamide 123I-IMP images and FAIR images obtained with a TI of 1400 milliseconds. On post-acetazolamide images, a higher correlation is observed between 123I-IMP images and FAIR images obtained with a TI of 1200 milliseconds.
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