Quantitative Assessment of Polymerization-Binding Mechanics of Cyanoacrylates: Model Development and Validation
Purushothaman Kailasnatha and
John C. Chaloupkab
a Division of Imaging Science, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT
b the Section of Interventional Neuroradiology, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA
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FIG 1. Schematic of dynamic test facility shows essential components of the apparatus.
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FIG 2. Photograph of dynamic test facility. Details of region indicated by arrow are shown in Figure 1. Traction device used to draw sliding bed away from load cell assembly can be seen at lower right.
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FIG 3. Schematic of evolution of polymerization forces. Multiphasic pattern of polymerization/binding, consisting of three phases of distinctive force-time curves, was observed in all experiments.
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FIG 4. Example of increased variability noted in phase II, which appeared to be most sensitive to subtle variations in injection conditions. Evolution of binding forces of industrial cyanoacrylate injected into plasma substitute is shown.
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FIG 5. Illustration shows influence of plasma substitute and blood on CES-nBCA polymerization. Subst, substitute.
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FIG 6. Phase I polymerization rates for CES-nBCA and Histoacryl in plasma substitute.
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