Cortical Dysplasia Localized by [11C]Methionine Positron Emission Tomography: Case Report
Padma Vasantha Madakasiraa,
Robert Simkinsa,
Tanjore Narayananb,
Kelly Duniganb,
Raymond J. Poelstraa and
Joseph Mantilb
a Wallace Kettering Neuroscience Institute, Kettering Medical Center, Kettering, OH
b Department of Nuclear Medicine & PET, Kettering Medical Center, Kettering, OH
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FIG 1. Images from the case of a 34-year-old woman who presented with medically intractable epilepsy of complex partial and left visual seizures.
A, Contrast-enhanced MR image (MRI) of the brain shows thickening within the right occipital lobe and in the posterior aspect of the right temporal lobe, suggestive of polymicrogyria/pachygyria.
B, [18F]Fluorodeoxyglucose positron emission tomographic scan (FDG-PET) of the brain shows focal area of decreased glucose uptake in the right occipital lobe.
C, [11C]Methionine positron emission tomographic scan (MET-PET) of the brain shows enhanced methionine uptake in the right occipital lobe.
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FIG 2. Balloon cell changes (arrow). Balloon cells have eccentric nuclei and abundant opalescent eosinophilic cytomplasm (hematoxylin and eosin; original magnification, x400).
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