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AJNR - American Journal of Neuroradiology

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Proton Magnetic Resonance Spectroscopy of the Thalamus in Patients with Chronic Neuropathic Pain after Spinal Cord Injury

Pradip M. Pattany^a, Robert P. Yezierski^d, Eva G. Widerström-Noga^b, Brian C. Bowen^a, Alberto. Martinez-Arizala^c, Bernardo R. Garcia^a and Robert M. Quencer^a

^a Department of Radiology, University of Miami School of Medicine
^b Miami Project to Cure Paralysis, University of Miami School of Medicine
^c Department of Neurology, University of Miami School of Medicine
^d Department of Orthodontics, University of Florida Gainesville, FL

View larger version (78K): [in a new window]   FIG 1. Axial T1-weighted image shows the location of the 2 x 2 x 2-cm voxel in the region of the left thalamus and the corresponding location of the right thalamus. MR spectroscopic data were separately acquired from each voxel for the three groups: SCI patients with pain, SCI patients without pain, and healthy control subjects. FIG 2. Typical single-voxel stimulated echo acquisition mode spectrum from a healthy control subject. The assignment of peaks to various cerebral metabolites and the spectral analysis are described in Methods.