AJDRAJNR - American Journal of Neuroradiology

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Decline in Corpus Callosum Volume among Pediatric Patients with Medulloblastoma: Longitudinal MR Imaging Study

Shawna L. Palmera, Wilburn E. Reddickb,f, John O. Glassb, Amar Gajjarc,e, Olga Goloubevad and Raymond K. Mulherna,e

a Division of Behavioral Medicine, St. Jude Children’s Research Hospital, TN
b Department of Diagnostic Imaging, St. Jude Children’s Research Hospital, TN
c Department of Hematology/Oncology, St. Jude Children’s Research Hospital, TN
d Department of Biostatistics and Epidemiology, St. Jude Children’s Research Hospital, TN
e Department of Pediatrics, University of Tennessee College of Medicine, TN
f Departments of Electrical and Computer Engineering and Biomedical Engineering, University of Memphis, Memphis, TN



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FIG 1. Corpus callosum subregions. 1, rostrum; 2, genu; 3, rostral body; 4, anterior midbody; 5, posterior midbody; 6, isthmus; and 7, splenium. Based on division of the longest anteroposterior (A-P) line.



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FIG 2. Expected growth (mm2/y) for the normal population (dashed line) and obtained growth among the patients with medulloblastoma (solid line) over time (in years) from the start of craniospinal irradiation. A, total corpus callosum; B, rostrum; C, genu; and D, rostral body.



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FIG 3. Expected growth (mm2/y) for the normal population (dashed line) and obtained growth among the patients with medulloblastoma (solid line) over time (in years) from the start of craniospinal irradiation. A, anterior midbody; B, posterior midbody; C, isthmus; D, splenium.