Healing Response in Elastase-Induced Rabbit Aneurysms after Embolization with a New Platinum Coil System
Naomi H. Fujiwaraa and
David F. Kallmesa
a From the Department of Radiology, University of Virginia Health Services, Charlottesville
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FIG 1. Subject 3, 2-week implantation.
A, DSA image obtained before embolization. Aneurysm measures 3.8 x 3 x 10 mm (width x neck x length).
B, DSA image obtained immediately after embolization shows 95% occlusion and a tiny triangular neck remnant (arrow).
C, Angiogram obtained before animal was sacrificed and 2 weeks after coil embolization shows complete occlusion.
D, Photomicrograph reveals unorganized blood filling the aneurysmal cavity. The neck of the aneurysm is covered with a thin, fibrin rim (hematoxylin-eosin stain, original magnification x 6.3).
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FIG 2. Subject 7, 4-week implantation.
A, DSA obtained image before embolization. The aneurysm is 4.9 x 5.1 x 6.5 mm (width x neck size x length).
B, DSA image obtained immediately after embolization depicts 95% occlusion.
C, Angiogram obtained before euthanasia and 4 weeks after coil implantation shows no change.
D, Photomicrograph reveals mostly unorganized blood filling the aneurysmal cavity and a thin fibrin rim covering the coils (arrows) (hematoxylin-eosin stain, original magnification x6.3). The neck of the aneurysm is covered with thin fibrin rim (arrowheads).
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FIG 3. Subject 13, 12-week implantation.
A, DSA image obtained before embolization. The aneurysm is 3.6 x 3.9 x 4.1 mm (width x neck size x length).
B, DSA image obtained immediately after embolization depicts 100% occlusion.
C, DSA image obtained before euthanasia and 12 weeks after coil implantation shows no change.
D, Photomicrograph shows that the aneurysmal cavity is filled with coils and well-organized tissue, with no residual thrombus (hematoxylin-eosin stain, original magnification x12.5). Minimal tissue thickness is present over the coils (arrows).
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FIG 4. Subject 16, 24-week implantation.
A, DSA image obtained before embolization. The aneurysm is 5.4 x 4.9 x 12.2 mm (width x neck size x length).
B, DSA image obtained immediately after embolization depicts 90% occlusion with a single coil loop in the parent artery (arrow).
C, DSA image obtained before euthanasia and 6 months after coil implantation shows no change.
D, Three distinct regions were present at histologic analysis. The distal dome is filled with organized tissue (short straight arrows). The midportion of the dome demonstrates unorganized thrombus (long straight arrows). The neck region (curved arrow) shows persistent flow and probably coil compaction, which was difficult to identify at angiography (hematoxylin-eosin stain, original magnification x8.3).
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FIG 5. Subject 15, 24-week implantation.
A, DSA image obtained before embolization. The aneurysm is 4.1 x 4.5 x 6.5 mm (width x neck size x length).
B, DSA image obtained immediately after embolization depicts 95% occlusion.
C, DSA image obtained before euthanasia and 6 months after coil implantation demonstrates persistent flow at the aneurysmal neck but no change in the percentage occlusion.
D, The aneurysm is filled with organized tissue (hematoxylin-eosin stain, original magnification x8.3).
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AJNR - American Journal of Neuroradiology