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AJNR - American Journal of Neuroradiology

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Angiographic Quantification of Contrast Medium Washout from Cerebral Aneurysms after Stent Placement

Chander Sadasivan^a, Baruch B. Lieber^c,d, Matthew J. Gounis^c, Demetrius K. Lopes^e and L. N. Hopkins^b

^a Department of Mechanical Engineering, State University of New York at Buffalo
^b Department of Neurosurgery, State University of New York at Buffalo
^c Department of Biomedical Engineering, University of Miami, FL
^d Department of Radiology, University of Miami, FL
^e Department of Neurosurgery, Rush-Presbyterian Medical Center, Chicago, IL

View larger version (15K): [in a new window]   FIG 1. Geometry and 3D image of the aneurysm model.

View larger version (15K): [in a new window]   FIG 2. Schematic diagram of the experimental setup.

View larger version (70K): [in a new window]   FIG 3. Images in patient 1. A, Angiogram illustrates the selection of an ROI. B, Final mask.

View larger version (16K): [in a new window]   FIG 4. Gray-scale intensity curves before and after stent placement. A, In vitro study. B, Raw data curves in patient 1 (AP projection).

View larger version (15K): [in a new window]   FIG 5. Top, Lagged normal distribution representing convective portion of model. Bottom, Diffusive component of the model. Dotted line indicates the sigmoid constituent; dashed line, the element of exponential decay.

View larger version (18K): [in a new window]   FIG 6. Model fits for the in vitro experiment (frame rate, 10 fps). Dotted line indicates data; solid line, model; dashed line and dash-and-dotted line, convection and diffusion components, respectively. A, Before stent placement. B, After stent placement.

View larger version (64K): [in a new window]   FIG 7. Variation in model parameters for the in vitro experiment, before and after stent placement. Values correspond to the model-fit curves in shown Figure 6.

View larger version (18K): [in a new window]   FIG 8. Model fit for patient 1 (AP projection; frame rate, 15 fps). Left, Before stent placement. Right, After stent placement. Dotted line represents data; solid line, the model; dashed line and dash-and-dotted line, convection and diffusion components of the model, respectively.

View larger version (65K): [in a new window]   FIG 9. Variation in model parameters for patient 1, before and after stent placement. Values correspond to the model-fit curves shown in Figure 8.

View larger version (154K): [in a new window]   FIG 10. Angiogram obtained at 3-month follow-up in patient 1 shows complete exclusion of the aneurysm from the circulation (AP projection).