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AJNR - American Journal of Neuroradiology

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Hemodynamic Response Changes in Cerebrovascular Disease: Implications for Functional MR Imaging

Leo M. Carusone^a, Jayashree Srinivasan^b, Darren R. Gitelman^c,d, M. Marsel Mesulam^d and Todd B. Parrish^a,c

^a Feinberg Clinical Neuroscience Research Institute, Chicago, Illinois
^b Department of Neurosurgery, Northwestern University Medical School, Chicago, Illinois
^c Department of Radiology, Northwestern University Medical School, Chicago, Illinois
^d Department of Neurology, Northwestern University Medical School, Chicago, Illinois

View larger version (83K): [in a new window]   FIG 1. A and B, Functional maps generated from the event-related, visually cued bilateral motor task for a patient with occlusion of the right internal carotid artery. Two axial images are shown with a cross-correlation threshold of r > 0.3. Note that the motor cortex ipsilateral to the lesion (right side) shows minimal or absent activation as a result of the occluded right internal carotid artery (blue circle), a finding corroborated by the blood flow velocity results of the transcranial Doppler US examination.

View larger version (83K): [in a new window]   FIG 2. A and B, Functional maps generated from the block motor task for a right internal carotid artery occlusion (same patients as in Figure 1). Two axial images are shown at the same anatomic level as that obtained for the event-related maps in Figure 1, but with a cross-correlation threshold of r > 0.45. Note the strong bilateral activation in the motor cortex.

View larger version (23K): [in a new window]   FIG 3. The BOLD signal time courses for a representative patient with an occlusion of the right internal carotid artery (same patients as in Figures 1 and 2). Event-related paradigm curves show the hemodynamic response functions for the right motor cortex (black curve) and left motor cortex (gray curve). The black box denotes the timing of the stimulus (Stim). A decrease in amplitude and delay in onset of the hemodynamic response function exists in the hemisphere ipsilateral to the occlusion (black curve).