Human Brain Hemorrhage: Quantification of Perihematoma Edema by Use of Diffusion-Weighted MR Imaging
J. Ricardo Carhuapomaa,
Peter B. Barkerc,
Daniel F. Hanleyb,
Paul Wangc and
Norman J. Beauchampc
a Neurosciences Critical Care and Stroke Program, Wayne State University School of Medicine, Detroit, MI
b Division of Neurosciences Critical Care, The Johns Hopkins Medical Institutions, Baltimore, MD
c Division of Neuroradiology, The Johns Hopkins Medical Institutions, Baltimore, MD
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FIG 1. MR images of two patients with ICH show the presence of a hyperintense halo on T2-weighted MR images (T2 MRI) and elevated ADC values in corresponding brain regions on diffusion-weighted images. Both characteristics are compatible with elevated interstitial tissue water content, suggestive of vasogenic brain edema. The diffusion-weighted images show regions of interest in the perihematoma tissue and in the contralateral hemisphere that were chosen for ADC analysis.
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FIG 2. Significant correlation between blood clot volume and ADC in the perihematoma tissue surrounding edema in nine patients with ICH (Pearson correlation coefficient 0.7, P=.04).
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FIG 3. Significant correlation between blood clot volume and ADC in corresponding homologous brain regions contralateral to the high T2 signal intensity perihematoma halo used as surrogate of vasogenic brain edema in nine patients with ICH (Pearson correlation coefficient 0.8, P=.02).
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